In a bowl, combine the ground beef, garlic powder, onion powder, salt, and pepper. Mix until just combined, being careful not to overmix.

Form the beef into a hamburger shape.

Preheat a grill or skillet over medium-high heat. Once hot, cook the patty for 3-4 minutes on each side, or until it reaches your desired level of doneness.

During the last minute of cooking, place cheddar cheese on the patty and cover the grill or skillet to melt the cheese.

To assemble the burger, place the cooked patty with melted cheese on the bottom half of the bun. Spread ketchup on the top half of the bun, then place it on top of the burger. Feel free to add any other low-calorie toppings or condiments.